Leducq Transatlantic Network of Excellence to Cure Phospholamban-Induced Cardiomyopathy (CURE-PLaN).
Doevendans PA, Glijnis PC, Kranias EG.
Circ Res. 2019 Sep 13;125(7):720-724
PMID: 31513489 [PubMed - in process]
Related citations
Featured characteristics and pivotal roles of satellite cells in skeletal muscle regeneration.
Song T, Sadayappan S.
J Muscle Res Cell Motil. 2019 Sep 07;:
PMID: 31494813 [PubMed - as supplied by publisher]
Related citations
KLF2 in Myeloid Lineage Cells Regulates the Innate Immune Response during Skeletal Muscle Injury and Regeneration.
Manoharan P, Song T, Radzyukevich TL, Sadayappan S, Lingrel JB, Heiny JA.
iScience. 2019 Jul 26;17:334-346
PMID: 31326700 [PubMed]
Related citations
Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction.
Alam P, Haile B, Arif M, Pandey R, Rokvic M, Nieman M, Maliken BD, Paul A, Wang YG, Sadayappan S, Ahmed RPH, Kanisicak O.
J Am Heart Assoc. 2019 Aug 06;8(15):e012089
PMID: 31315484 [PubMed - in process]
Related citations
The potential role of neddylation in pre- and postnatal cardiac remodeling.
Sadayappan S, Gilbert RJ.
Am J Physiol Heart Circ Physiol. 2019 Aug 01;317(2):H276-H278
PMID: 31274350 [PubMed - indexed for MEDLINE]
Related citations
Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin.
McNamara JW, Singh RR, Sadayappan S.
Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11731-11736
PMID: 31142654 [PubMed - in process]
Related citations
Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy.
Kuster DWD, Lynch TL, Barefield DY, Sivaguru M, Kuffel G, Zilliox MJ, Lee KH, Craig R, Namakkal-Soorappan R, Sadayappan S.
Cardiovasc Res. 2019 May 03;:
PMID: 31050699 [PubMed - as supplied by publisher]
Related citations
Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy.
Tabish AM, Arif M, Song T, Elbeck Z, Becker RC, Knöll R, Sadayappan S.
Am J Physiol Heart Circ Physiol. 2019 Jul 01;317(1):H168-H180
PMID: 31026178 [PubMed - in process]
Related citations
Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle.
Goh Q, Song T, Petrany MJ, Cramer AA, Sun C, Sadayappan S, Lee SJ, Millay DP.
Elife. 2019 Apr 23;8:
PMID: 31012848 [PubMed - in process]
Related citations
ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity.
Boyer JG, Prasad V, Song T, Lee D, Fu X, Grimes KM, Sargent MA, Sadayappan S, Molkentin JD.
JCI Insight. 2019 Apr 09;5:
PMID: 30964448 [PubMed - in process]
Related citations
Epigenetic modification: a regulatory mechanism in essential hypertension.
Arif M, Sadayappan S, Becker RC, Martin LJ, Urbina EM.
Hypertens Res. 2019 Aug;42(8):1099-1113
PMID: 30867575 [PubMed - in process]
Related citations
Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.
Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Varró A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S.
J Mol Cell Cardiol. 2019 Apr;129:236-246
PMID: 30862451 [PubMed - in process]
Related citations
The rapid proliferation of solicited content online journals: a quest to disseminate knowledge?
Becker RC, Cotarlan V, Sadayappan S.
J Thromb Thrombolysis. 2019 Apr;47(3):337-344
PMID: 30806870 [PubMed - in process]
Related citations
Cardiovascular Leaders Are Made, not Born.
Sadayappan S.
Circ Res. 2019 Feb 15;124(4):484-487
PMID: 30763211 [PubMed - in process]
Related citations
Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation.
Song T, Manoharan P, Millay DP, Koch SE, Rubinstein J, Heiny JA, Sadayappan S.
Skelet Muscle. 2019 01 24;9(1):4
PMID: 30678732 [PubMed - indexed for MEDLINE]
Related citations
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.
Toepfer CN, Wakimoto H, Garfinkel AC, McDonough B, Liao D, Jiang J, Tai AC, Gorham JM, Lunde IG, Lun M, Lynch TL, McNamara JW, Sadayappan S, Redwood CS, Watkins HC, Seidman JG, Seidman CE.
Sci Transl Med. 2019 Jan 23;11(476):
PMID: 30674652 [PubMed - in process]
Related citations
Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.
Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J.
Circ Res. 2019 Jan 18;124(2):292-305
PMID: 30582455 [PubMed - in process]
Related citations
MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy.
O'Leary TS, Snyder J, Sadayappan S, Day SM, Previs MJ.
J Mol Cell Cardiol. 2019 Feb;127:165-173
PMID: 30550750 [PubMed - in process]
Related citations
Basic Cardiovascular Sciences Scientific Sessions 2018.
McNamara JW, Grimes KM, Sadayappan S.
Circ Res. 2018 Oct 12;123(9):1024-1029
PMID: 30355166 [PubMed - in process]
Related citations
Skeletal myosin binding protein-C: An increasingly important regulator of striated muscle physiology.
McNamara JW, Sadayappan S.
Arch Biochem Biophys. 2018 12 15;660:121-128
PMID: 30339776 [PubMed - indexed for MEDLINE]
Related citations
Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3Δ25bpIntronic Deletion in South Asian Descendants.
Viswanathan SK, Puckelwartz MJ, Mehta A, Ramachandra CJA, Jagadeesan A, Fritsche-Danielson R, Bhat RV, Wong P, Kandoi S, Schwanekamp JA, Kuffel G, Pesce LL, Zilliox MJ, Durai UNB, Verma RS, Molokie RE, Suresh DP, Khoury PR, Thomas A, Sanagala T, Tang HC, Becker RC, Knöll R, Shim W, McNally EM, Sadayappan S.
JAMA Cardiol. 2018 Jun 01;3(6):481-488
PMID: 29641836 [PubMed - in process]
Related citations
My Life, My Heart, and My(osin) Binding Protein-C.
Sadayappan S.
Circ Res. 2018 03 30;122(7):918-920
PMID: 29599274 [PubMed - indexed for MEDLINE]
Related citations
Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes.
Smyrnias I, Goodwin N, Wachten D, Skogestad J, Aronsen JM, Robinson EL, Demydenko K, Segonds-Pichon A, Oxley D, Sadayappan S, Sipido K, Bootman MD, Roderick HL.
J Mol Cell Cardiol. 2018 04;117:1-18
PMID: 29470978 [PubMed - indexed for MEDLINE]
Related citations
Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.
Huang W, Feng Y, Liang J, Yu H, Wang C, Wang B, Wang M, Jiang L, Meng W, Cai W, Medvedovic M, Chen J, Paul C, Davidson WS, Sadayappan S, Stambrook PJ, Yu XY, Wang Y.
Nat Commun. 2018 02 16;9(1):700
PMID: 29453456 [PubMed - indexed for MEDLINE]
Related citations
Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner.
Lin BL, Li A, Mun JY, Previs MJ, Previs SB, Campbell SG, Dos Remedios CG, Tombe PP, Craig R, Warshaw DM, Sadayappan S.
Sci Rep. 2018 02 08;8(1):2604
PMID: 29422607 [PubMed - indexed for MEDLINE]
Related citations
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.
Robbins N, Gilbert M, Kumar M, McNamara JW, Daly P, Koch SE, Conway G, Effat M, Woo JG, Sadayappan S, Rubinstein J.
J Am Heart Assoc. 2018 01 13;7(2):
PMID: 29331959 [PubMed - in process]
Related citations
Hypertrophic cardiomyopathy clinical phenotype is independent of gene mutation and mutation dosage.
Viswanathan SK, Sanders HK, McNamara JW, Jagadeesan A, Jahangir A, Tajik AJ, Sadayappan S.
PLoS One. 2017;12(11):e0187948
PMID: 29121657 [PubMed - indexed for MEDLINE]
Related citations
MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents.
Arif M, Pandey R, Alam P, Jiang S, Sadayappan S, Paul A, Ahmed RPH.
J Mol Med (Berl). 2017 Dec;95(12):1369-1385
PMID: 28948298 [PubMed - indexed for MEDLINE]
Related citations
The Myofilament Field Revisited in the Age of Cellular and Molecular Biology.
Sadayappan S.
Circ Res. 2017 09 01;121(6):601-603
PMID: 28860317 [PubMed - indexed for MEDLINE]
Related citations
Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events.
Tong CW, Dusio GF, Govindan S, Johnson DW, Kidwell DT, De La Rosa LM, Rosas PC, Liu Y, Ebert E, Newell-Rogers MK, Michel JB, Trzeciakowski JP, Sadayappan S.
Am J Cardiol. 2017 Nov 01;120(9):1501-1507
PMID: 28847594 [PubMed - indexed for MEDLINE]
Related citations
The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.
Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R.
Pflugers Arch. 2017 Dec;469(12):1603-1613
PMID: 28780592 [PubMed - indexed for MEDLINE]
Related citations
Cardiovascular Early Careers: Past and Present.
Sadayappan S.
Circ Res. 2017 07 07;121(2):100-102
PMID: 28684620 [PubMed - indexed for MEDLINE]
Related citations
Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome.
Lynch TL, Kuster DWD, Gonzalez B, Balasubramanian N, Nair N, Day S, Calvino JE, Tan Y, Liebetrau C, Troidl C, Hamm CW, Güçlü A, McDonough B, Marian AJ, van der Velden J, Seidman CE, Huggins GS, Sadayappan S.
JACC Basic Transl Sci. 2017 Apr;2(2):122-131
PMID: 28596995 [PubMed]
Related citations
Application of an advanced maximum likelihood estimation restoration method for enhanced-resolution and contrast in second-harmonic generation microscopy.
Sivaguru M, Kabir MM, Gartia MR, Biggs DSC, Sivaguru BS, Sivaguru VA, Fried GA, Liu GL, Sadayappan S, Toussaint KC.
J Microsc. 2017 09;267(3):397-408
PMID: 28594468 [PubMed - indexed for MEDLINE]
Related citations
Myofilaments: Movers and Rulers of the Sarcomere.
Lin BL, Song T, Sadayappan S.
Compr Physiol. 2017 03 16;7(2):675-692
PMID: 28333386 [PubMed - indexed for MEDLINE]
Related citations
High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant.
Barefield DY, Lynch TL, Jagadeesan A, Sanagala T, Sadayappan S.
J Mol Biomark Diagn. 2016 Nov;7(6):
PMID: 27990320 [PubMed]
Related citations
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.
Lynch TL, Ismahil MA, Jegga AG, Zilliox MJ, Troidl C, Prabhu SD, Sadayappan S.
J Mol Cell Cardiol. 2017 01;102:83-93
PMID: 27955979 [PubMed - indexed for MEDLINE]
Related citations
Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian Descendants.
Kraker J, Viswanathan SK, Knöll R, Sadayappan S.
Front Physiol. 2016;7:499
PMID: 27840609 [PubMed]
Related citations
Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review.
Hoffman MP, Taylor EN, Aninwene GE, Sadayappan S, Gilbert RJ.
Microsc Res Tech. 2018 Feb;81(2):162-170
PMID: 27696640 [PubMed - indexed for MEDLINE]
Related citations
N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro.
Lipps C, Nguyen JH, Pyttel L, Lynch TL, Liebetrau C, Aleshcheva G, Voss S, Dörr O, Nef HM, Möllmann H, Hamm CW, Sadayappan S, Troidl C.
J Mol Cell Cardiol. 2016 Oct;99:47-56
PMID: 27616755 [PubMed - indexed for MEDLINE]
Related citations
Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C.
Taylor EN, Hoffman MP, Barefield DY, Aninwene GE, Abrishamchi AD, Lynch TL, Govindan S, Osinska H, Robbins J, Sadayappan S, Gilbert RJ.
J Am Heart Assoc. 2016 Mar 15;5(3):e002836
PMID: 27068630 [PubMed - indexed for MEDLINE]
Related citations
S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.
Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, van der Velden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F.
FASEB J. 2016 05;30(5):1849-64
PMID: 26839380 [PubMed - indexed for MEDLINE]
Related citations
Cardiac muscle organization revealed in 3-D by imaging whole-mount mouse hearts using two-photon fluorescence and confocal microscopy.
Sivaguru M, Fried G, Sivaguru BS, Sivaguru VA, Lu X, Choi KH, Saif MT, Lin B, Sadayappan S.
Biotechniques. 2015 Nov;59(5):295-308
PMID: 26554507 [PubMed - indexed for MEDLINE]
Related citations
Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.
Lynch TL, Sivaguru M, Velayutham M, Cardounel AJ, Michels M, Barefield D, Govindan S, dos Remedios C, van der Velden J, Sadayappan S.
Oxid Med Cell Longev. 2015;2015:424751
PMID: 26508994 [PubMed - indexed for MEDLINE]
Related citations
Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate.
Thoonen R, Giovanni S, Govindan S, Lee DI, Wang GR, Calamaras TD, Takimoto E, Kass DA, Sadayappan S, Blanton RM.
Circ Heart Fail. 2015 Nov;8(6):1115-22
PMID: 26477830 [PubMed - indexed for MEDLINE]
Related citations
Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.
Kumar M, Govindan S, Zhang M, Khairallah RJ, Martin JL, Sadayappan S, de Tombe PP.
J Biol Chem. 2015 Dec 04;290(49):29241-9
PMID: 26453301 [PubMed - indexed for MEDLINE]
Related citations
Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or β1-Adrenergic Stimulation.
Tong CW, Wu X, Liu Y, Rosas PC, Sadayappan S, Hudmon A, Muthuchamy M, Powers PA, Valdivia HH, Moss RL.
Circ Heart Fail. 2015 May;8(3):595-604
PMID: 25740838 [PubMed - indexed for MEDLINE]
Related citations
A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction.
Kuster DW, Govindan S, Springer TI, Martin JL, Finley NL, Sadayappan S.
J Biol Chem. 2015 Feb 27;290(9):5855-67
PMID: 25583989 [PubMed - indexed for MEDLINE]
Related citations
Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.
Barefield D, Kumar M, Gorham J, Seidman JG, Seidman CE, de Tombe PP, Sadayappan S.
J Mol Cell Cardiol. 2015 Feb;79:234-43
PMID: 25463273 [PubMed - indexed for MEDLINE]
Related citations
Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM.
Lee K, Harris SP, Sadayappan S, Craig R.
J Mol Biol. 2015 Jan 30;427(2):274-86
PMID: 25451032 [PubMed - indexed for MEDLINE]
Related citations
Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner.
Wang L, Sadayappan S, Kawai M.
PLoS One. 2014;9(11):e113417
PMID: 25420047 [PubMed - indexed for MEDLINE]
Related citations
Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation.
Simon JN, Chowdhury SA, Warren CM, Sadayappan S, Wieczorek DF, Solaro RJ, Wolska BM.
Basic Res Cardiol. 2014;109(6):445
PMID: 25280528 [PubMed - indexed for MEDLINE]
Related citations
Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure.
Wilson K, Guggilam A, West TA, Zhang X, Trask AJ, Cismowski MJ, de Tombe P, Sadayappan S, Lucchesi PA.
Am J Physiol Heart Circ Physiol. 2014 Dec 01;307(11):H1605-17
PMID: 25260618 [PubMed - indexed for MEDLINE]
Related citations
Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy.
Helms AS, Davis FM, Coleman D, Bartolone SN, Glazier AA, Pagani F, Yob JM, Sadayappan S, Pedersen E, Lyons R, Westfall MV, Jones R, Russell MW, Day SM.
Circ Cardiovasc Genet. 2014 Aug;7(4):434-43
PMID: 25031304 [PubMed - indexed for MEDLINE]
Related citations
Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction.
Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, Möllmann H.
PLoS One. 2014;9(6):e98456
PMID: 24893162 [PubMed - indexed for MEDLINE]
Related citations
Surviving the infarct: A profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium.
Lynch TL, Sadayappan S.
Proteomics Clin Appl. 2014 Aug;8(7-8):569-77
PMID: 24888514 [PubMed - indexed for MEDLINE]
Related citations
Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner.
Wang L, Ji X, Barefield D, Sadayappan S, Kawai M.
Biophys J. 2014 Mar 04;106(5):1112-22
PMID: 24606935 [PubMed - indexed for MEDLINE]
Related citations
Transmural heterogeneity of cellular level power output is reduced in human heart failure.
Haynes P, Nava KE, Lawson BA, Chung CS, Mitov MI, Campbell SG, Stromberg AJ, Sadayappan S, Bonnell MR, Hoopes CW, Campbell KS.
J Mol Cell Cardiol. 2014 Jul;72:1-8
PMID: 24560668 [PubMed - indexed for MEDLINE]
Related citations
Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium.
Witayavanitkul N, Ait Mou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, de Tombe PP, Sadayappan S.
J Biol Chem. 2014 Mar 28;289(13):8818-27
PMID: 24509847 [PubMed - indexed for MEDLINE]
Related citations
Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.
Barefield D, Kumar M, de Tombe PP, Sadayappan S.
Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H807-15
PMID: 24464755 [PubMed - indexed for MEDLINE]
Related citations
Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury.
Kuster DW, Cardenas-Ospina A, Miller L, Liebetrau C, Troidl C, Nef HM, Möllmann H, Hamm CW, Pieper KS, Mahaffey KW, Kleiman NS, Stuyvers BD, Marian AJ, Sadayappan S.
Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H547-56
PMID: 24337456 [PubMed - indexed for MEDLINE]
Related citations
MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation.
Kuster DW, Sadayappan S.
Pflugers Arch. 2014 Feb;466(2):207-13
PMID: 24327208 [PubMed - indexed for MEDLINE]
Related citations
Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis.
Gao X, Lin B, Sadayappan S, Patel TB.
Mol Pharmacol. 2014 Feb;85(2):357-67
PMID: 24307699 [PubMed - indexed for MEDLINE]
Related citations
Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series.
Sadayappan S, de Tombe PP.
Pflugers Arch. 2014 Feb;466(2):195-200
PMID: 24196566 [PubMed - indexed for MEDLINE]
Related citations
Finding the missing link: disulfide-containing proteins via a high-throughput proteomics approach.
Khairallah RJ, Sadayappan S.
Proteomics. 2013 Nov;13(22):3245-6
PMID: 24150840 [PubMed - indexed for MEDLINE]
Related citations
Enhanced cardiac function in Gravin mutant mice involves alterations in the β-adrenergic receptor signaling cascade.
Guillory AN, Yin X, Wijaya CS, Diaz Diaz AC, Rababa'h A, Singh S, Atrooz F, Sadayappan S, McConnell BK.
PLoS One. 2013;8(9):e74784
PMID: 24058627 [PubMed - indexed for MEDLINE]
Related citations
A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay.
Kuster DW, Barefield D, Govindan S, Sadayappan S.
J Vis Exp. 2013 Aug 08;(78):
PMID: 23963065 [PubMed - indexed for MEDLINE]
Related citations
Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function.
Lin B, Govindan S, Lee K, Zhao P, Han R, Runte KE, Craig R, Palmer BM, Sadayappan S.
PLoS One. 2013;8(7):e69671
PMID: 23936073 [PubMed - indexed for MEDLINE]
Related citations
Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction.
Govindan S, Kuster DW, Lin B, Kahn DJ, Jeske WP, Walenga JM, Leya F, Hoppensteadt D, Fareed J, Sadayappan S.
Am J Cardiovasc Dis. 2013;3(2):60-70
PMID: 23785583 [PubMed]
Related citations
Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.
Hwang H, Robinson D, Rogers JB, Stevenson TK, Lang SE, Sadayappan S, Day SM, Sivaramakrishnan S, Westfall MV.
Sci Rep. 2013;3:1971
PMID: 23756828 [PubMed - indexed for MEDLINE]
Related citations
Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart.
Jin CZ, Jang JH, Kim HJ, Wang Y, Hwang IC, Sadayappan S, Park BM, Kim SH, Jin ZH, Seo EY, Kim KH, Kim YJ, Kim SJ, Zhang YH.
J Mol Cell Cardiol. 2013 Jul;60:107-15
PMID: 23624088 [PubMed - indexed for MEDLINE]
Related citations
Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations.
Sequeira V, Wijnker PJ, Nijenkamp LL, Kuster DW, Najafi A, Witjas-Paalberends ER, Regan JA, Boontje N, Ten Cate FJ, Germans T, Carrier L, Sadayappan S, van Slegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, Dos Remedios C, Stienen GJ, Ho CY, Michels M, van der Velden J.
Circ Res. 2013 May 24;112(11):1491-505
PMID: 23508784 [PubMed - indexed for MEDLINE]
Related citations
GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication.
Kuster DW, Sequeira V, Najafi A, Boontje NM, Wijnker PJ, Witjas-Paalberends ER, Marston SB, Dos Remedios CG, Carrier L, Demmers JA, Redwood C, Sadayappan S, van der Velden J.
Circ Res. 2013 Feb 15;112(4):633-9
PMID: 23277198 [PubMed - indexed for MEDLINE]
Related citations
In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure.
Guggilam A, Hutchinson KR, West TA, Kelly AP, Galantowicz ML, Davidoff AJ, Sadayappan S, Lucchesi PA.
J Mol Cell Cardiol. 2013 Apr;57:47-58
PMID: 23220155 [PubMed - indexed for MEDLINE]
Related citations
Cardiac myosin binding protein-C: redefining its structure and function.
Sadayappan S, de Tombe PP.
Biophys Rev. 2012 Jun 01;4(2):93-106
PMID: 22707987 [PubMed]
Related citations
Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB.
Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh AK, Kishore R.
Circulation. 2012 Jul 24;126(4):418-29
PMID: 22705886 [PubMed - indexed for MEDLINE]
Related citations
Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315.
Dirkx E, Cazorla O, Schwenk RW, Lorenzen-Schmidt I, Sadayappan S, Van Lint J, Carrier L, van Eys GJ, Glatz JF, Luiken JJ.
Am J Physiol Heart Circ Physiol. 2012 Aug 01;303(3):H323-31
PMID: 22636676 [PubMed - indexed for MEDLINE]
Related citations
PKCβII modulation of myocyte contractile performance.
Hwang H, Robinson DA, Stevenson TK, Wu HC, Kampert SE, Pagani FD, Dyke DB, Martin JL, Sadayappan S, Day SM, Westfall MV.
J Mol Cell Cardiol. 2012 Aug;53(2):176-86
PMID: 22587992 [PubMed - indexed for MEDLINE]
Related citations
Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A.
Hinken AC, Hanft LM, Scruggs SB, Sadayappan S, Robbins J, Solaro RJ, McDonald KS.
J Muscle Res Cell Motil. 2012 Dec;33(6):439-48
PMID: 22527640 [PubMed - indexed for MEDLINE]
Related citations
Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro.
Govindan S, Sarkey J, Ji X, Sundaresan NR, Gupta MP, de Tombe PP, Sadayappan S.
J Muscle Res Cell Motil. 2012 May;33(1):17-30
PMID: 22527638 [PubMed - indexed for MEDLINE]
Related citations
Cardiac myosin binding protein-C: a potential early-stage, cardiac-specific biomarker of ischemia-reperfusion injury.
Sadayappan S.
Biomark Med. 2012 Feb;6(1):69-72
PMID: 22296197 [PubMed - indexed for MEDLINE]
Related citations
Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain.
Howarth JW, Ramisetti S, Nolan K, Sadayappan S, Rosevear PR.
J Biol Chem. 2012 Mar 09;287(11):8254-62
PMID: 22235120 [PubMed - indexed for MEDLINE]
Related citations
Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function.
van Dijk SJ, Paalberends ER, Najafi A, Michels M, Sadayappan S, Carrier L, Boontje NM, Kuster DW, van Slegtenhorst M, Dooijes D, dos Remedios C, ten Cate FJ, Stienen GJ, van der Velden J.
Circ Heart Fail. 2012 Jan;5(1):36-46
PMID: 22178992 [PubMed - indexed for MEDLINE]
Related citations
Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain.
Weith A, Sadayappan S, Gulick J, Previs MJ, Vanburen P, Robbins J, Warshaw DM.
J Mol Cell Cardiol. 2012 Jan;52(1):219-27
PMID: 21978630 [PubMed - indexed for MEDLINE]
Related citations
Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.
Govindan S, McElligott A, Muthusamy S, Nair N, Barefield D, Martin JL, Gongora E, Greis KD, Luther PK, Winegrad S, Henderson KK, Sadayappan S.
J Mol Cell Cardiol. 2012 Jan;52(1):154-64
PMID: 21971072 [PubMed - indexed for MEDLINE]
Related citations
Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime.
Palmer BM, Sadayappan S, Wang Y, Weith AE, Previs MJ, Bekyarova T, Irving TC, Robbins J, Maughan DW.
Biophys J. 2011 Oct 05;101(7):1661-9
PMID: 21961592 [PubMed - indexed for MEDLINE]
Related citations
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.
Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J.
Circ Res. 2011 Jul 08;109(2):141-50
PMID: 21597010 [PubMed - indexed for MEDLINE]
Related citations
Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation.
Cuello F, Bardswell SC, Haworth RS, Ehler E, Sadayappan S, Kentish JC, Avkiran M.
J Biol Chem. 2011 Feb 18;286(7):5300-10
PMID: 21148481 [PubMed - indexed for MEDLINE]
Related citations
Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle.
Copeland O, Sadayappan S, Messer AE, Steinen GJ, van der Velden J, Marston SB.
J Mol Cell Cardiol. 2010 Dec;49(6):1003-11
PMID: 20850451 [PubMed - indexed for MEDLINE]
Related citations
Parameterized Specification, Configuration and Execution of Data-Intensive Scientific Workflows.
Kumar VS, Kurc T, Ratnakar V, Kim J, Mehta G, Vahi K, Nelson YL, Sadayappan P, Deelman E, Gil Y, Hall M, Saltz J.
Cluster Comput. 2010 Sep;13(3):315-333
PMID: 22623878 [PubMed - as supplied by publisher]
Related citations
Targeted genome-wide enrichment of functional regions.
Senapathy P, Bhasi A, Mattox J, Dhandapany PS, Sadayappan S.
PLoS One. 2010 Jun 16;5(6):e11138
PMID: 20585402 [PubMed - indexed for MEDLINE]
Related citations
Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling.
Bardswell SC, Cuello F, Rowland AJ, Sadayappan S, Robbins J, Gautel M, Walker JW, Kentish JC, Avkiran M.
J Biol Chem. 2010 Feb 19;285(8):5674-82
PMID: 20018870 [PubMed - indexed for MEDLINE]
Related citations
Phosphorylation and function of cardiac myosin binding protein-C in health and disease.
Barefield D, Sadayappan S.
J Mol Cell Cardiol. 2010 May;48(5):866-75
PMID: 19962384 [PubMed - indexed for MEDLINE]
Related citations
Performance optimization of tensor contraction expressions for many-body methods in quantum chemistry.
Hartono A, Lu Q, Henretty T, Krishnamoorthy S, Zhang H, Baumgartner G, Bernholdt DE, Nooijen M, Pitzer R, Ramanujam J, Sadayappan P.
J Phys Chem A. 2009 Nov 12;113(45):12715-23
PMID: 19888780 [PubMed]
Related citations
Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.
Nicolaou P, Rodriguez P, Ren X, Zhou X, Qian J, Sadayappan S, Mitton B, Pathak A, Robbins J, Hajjar RJ, Jones K, Kranias EG.
Circ Res. 2009 Apr 24;104(8):1012-20
PMID: 19299645 [PubMed - indexed for MEDLINE]
Related citations
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.
Sadayappan S, Gulick J, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, Robbins J.
Circulation. 2009 Mar 10;119(9):1253-62
PMID: 19237661 [PubMed - indexed for MEDLINE]
Related citations
A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia.
Dhandapany PS, Sadayappan S, Xue Y, Powell GT, Rani DS, Nallari P, Rai TS, Khullar M, Soares P, Bahl A, Tharkan JM, Vaideeswar P, Rathinavel A, Narasimhan C, Ayapati DR, Ayub Q, Mehdi SQ, Oppenheimer S, Richards MB, Price AL, Patterson N, Reich D, Singh L, Tyler-Smith C, Thangaraj K.
Nat Genet. 2009 Feb;41(2):187-91
PMID: 19151713 [PubMed - indexed for MEDLINE]
Related citations
An Integrated Framework for Parameter-based Optimization of Scientific Workflows.
Kumar VS, Sadayappan P, Mehta G, Vahi K, Deelman E, Ratnakar V, Kim J, Gil Y, Hall M, Kurc T, Saltz J.
Proc Int Symp High Perform Distrib Comput. 2009;:177-186
PMID: 22068617 [PubMed - as supplied by publisher]
Related citations
The death of transcriptional chauvinism in the control and regulation of cardiac contractility.
Sadayappan S, Robbins J.
Ann N Y Acad Sci. 2008 Mar;1123:1-9
PMID: 18375572 [PubMed - indexed for MEDLINE]
Related citations
Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation.
Nagayama T, Takimoto E, Sadayappan S, Mudd JO, Seidman JG, Robbins J, Kass DA.
Circulation. 2007 Nov 20;116(21):2399-408
PMID: 17984378 [PubMed - indexed for MEDLINE]
Related citations

For queries and opportunities, Please Contact :

Sakthivel Sadayappan, PhD, MBA
Professor of Internal Medicine
Associate Chairman for Basic Research
Department of Internal Medicine
Director of Heart Branch of the Heart, Lung and Vascular Institute
Division of Cardiovascular Health and Disease
University of Cincinnati, College of Medicine
Cardiovascular Center, Rm 4935
231 Albert Sabin Way
Cincinnati, OH 45267-0542, USA
Phone : +1 513-558-7498
Email : sadayasl@ucmail.uc.edu

For lab research activities, news, events
meetings, conferences, symposiums
and outdoor activities,
found us and like us
at Sadayappan Lab Facebook