From University of Cincinnati since Aug 2016 :

Viswanathan SK, Puckelwartz MJ, Mehta A, Ramachandra CJA, Jagadeesan A, Danielson RF-5, Bhat RV, Wong P, Kandoi S, Schwanekamp JA, Kuffel G, Pesce LL, Zilliox MJ, Durai NB, Verma Molokie RE, Suresh DP, Khoury PR, Thomas A, Sanagala T, Tang HC, Becker RC, Knöll R, Shim W, McNally EM, and Sadayappan S.

Association of cardiomyopathy with MYBPC3 D389V and MYBPC3Δ25bp intronic deletion in South Asian Descendants. JAMA Cardiology. April 11, 2018 PMID: 29641836

Sadayappan S.

My life, My heart and My(osin) binding protein-C. Circ Res. 2018 Mar 30;122(7):918-920 PMID: 29599274

Smyrnias I, Goodwin N, Wachten D, Skogestad J, Aronsen JM, Robinson EL, Demydenko K, Segonds-Pichon A, Oxley D, Sadayappan S, Sipido K, Bootman MD, Llewelyn Roderick H.

Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes. J Mol Cell Cardiol. 2018 Feb 19. pii: S0022-2828(18)30046-4. doi: 10.1016/j.yjmcc.2018.02.012 PMID: 29470978

Huang W, Feng Y, Liang J, Yu H, Wang C, Wang B, Wang M, Jiang L, Meng W, Cai W, Medvedovic M, Chen J, Paul C, Davidson WS, Sadayappan S, Stambrook PJ, Yu XY, Wang Y.

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018 Feb 16;9(1):700 PMCID: PMC5816016

Lin BL, Li A, Mun JY, Previs MJ, Previs SB, Campbell SG, Dos Remedios CG, Tombe PP, Craig R, Warshaw DM, Sadayappan S.

Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner. Sci Rep. 2018 Feb 8;8(1):2604 PMCID: PMC5805719

Robbins N, Gilbert M, Kumar M, McNamara JW, Daly P, Koch SE, Conway G, Effat M, Woo JG, Sadayappan S, Rubinstein J.

Probenecid improves cardiac function in patients with heart failure with reduced ejection fraction in vivo and cardiomyocyte calcium sensitivity in vitro. J Am Heart Assoc. 2018 Jan 13;7(2) PMID: 29331959

Viswanathan SK, Sanders HK, McNamara JW, Jagadeesan A, Jahangir A, Tajik AJ, Sadayappan S.

Hypertrophic cardiomyopathy clinical phenotype is independent of gene mutation and mutation dosage. PLoS One. 2017 Nov 9;12(11):e0187948 PMCID: PMC5679632

Arif M, Pandey R, Alam P, Jiang S, Sadayappan S, Paul A, Ahmed RPH.

MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. J Mol Med (Berl). 2017 Dec;95(12):1369-1385 PMID: 28948298
Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP,

Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R.

The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. Manuscript accepted for publication in Pflugers Archiv. 2017; 469(12):1603-1613 PMID: 28780592

Sadayappan S.

The myofilament field revisited in the age of cellular and molecular biology. Circ Res. 2017 121(6):601-603 PMCID: PMC5658034

Tong CW, Dusio GF, Govindan S, Johnson DW, Kidwell DT, De La Rosa LM, Rosas PC, Liu Y, Ebert E, Newell-Rogers MK, Michel JB, Trzeciakowski JP,
Sadayappan S.

Usefulness of released cardiac myosin binding protein-C as a predictor of cardiovascular events. Am J Cardiol. 2017; 120(9):1501-1507 PMID: 28847594

Sadayappan S.

Cardiovascular early careers: past and future. Circ Res 2017 (121):100-102 PMCID: 28684620

Lynch TL, Kuster DWD, Gonzalez B, Balasubramanian N, Nair N, Day S, Calvino JE, Tan Y, Liebetrau C, Troidl C, Hamm CW, Güçlü A, McDonough B, Marian AJ, van der Velden J, Seidman CE, Huggins GS and Sadayappan S.

Cardiac Myosin Binding Protein-C Autoantibodies are potential early indicators of cardiac dysfunction and patient outcome in Acute Coronary Syndrome. JACC: Basic Transl Sci. 2017 (2): 122-131 PMCID: PMC5460768

Lin BL, Song T, Sadayappan S.

Myofilaments: Movers and Rulers of the Sarcomere Compr Physiol. 2017 Mar 16;7(2):675-692 PMID : 28333386

Barefield DY, Lynch TL 4th, Jagadeesan A, Sanagala T, Sadayappan S.

High-Throughput diagnostic assay for a highly prevalent cardiomyopathy-associated MYBPC3 variant. J Mol Biomark Diagn. 2016 Nov;7(6) PMC5160998

Lynch TL 4th, Ismahil MA, Jegga AG, Zilliox MJ, Troidl C, Prabhu SD, Sadayappan S.

Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation. J Mol Cell Cardiol. 2016 Dec 10;102:83-93 PMID: 27955979

Kraker J, Viswanathan SK, Knöll R, Sadayappan S.

Recent Advances in the Molecular genetics of familial hypertrophic cardiomyopathy in South Asian Descendants. Front Physiol. 2016 Oct 28;7:499 PMC5083855

From Loyola University Chicago since Sep 2009 :

Hoffman MP, Taylor EN, Aninwene GE 2nd, Sadayappan S, Gilbert RJ.

Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review. Microsc Res Tech. 2016 Oct 2. doi: 10.1002/jemt.22777. [Epubaheadofprint] PMID: 27696640

Lipps C, Nguyen JH, Pyttel L, Lynch TL 4th, Liebetrau C, Aleshcheva G, Voss S,Dörr O, NefHM, Möllmann H, Hamm CW, Sadayappan S, Troidl C.

N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro.J Mol Cell Cardiol. 2016 Oct;99:47-56 PMC5107329

Taylor EN, Hoffman MP, Barefield DY, Aninwene GE 2nd, Abrishamchi AD, Lynch TL 4th, Govindan S, Osinska H, Robbins J, Sadayappan S, Gilbert RJ.

Alterations in multi-scale cardiac architecture in association with phosphorylation of myosin binding protein-C. J Am Heart Assoc. 2016 Mar 15;5(3):e002836 PMC4943261

Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, vanderVelden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F.

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure. FASEBJ. 2016 May;30(5):1849-64 PMC4836368

Sivaguru M, Fried G, Sivaguru BS, Sivaguru VA, LuX, Choi KH, Saif MT, Lin B, Sadayappan S.

Cardiac muscle organization revealed in 3-D by imaging whole-mount mouse hearts using two-photon fluorescence and confocal microscopy. Biotechniques. 2015 Nov 1;59(5):295-308PMID:26554507

Lynch TL 4th, Sivaguru M, Velayutham M, Cardounel AJ, Michels M, Barefield D,Govindan S, dosRemedios C, vander Velden J, Sadayappan S.

Oxidative Stress in Dilated cardiomyopathy caused by MYBPC3 mutation. Oxid Med Cell Longev. 2015;2015:424751 PMC4609873

Thoonen R, Giovanni S, Govindan S, Lee DI, Wang GR, Calamaras TD, Takimoto E, Kass DA, Sadayappan S, Blanton RM.

Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G- Iα Substrate. Circ Heart Fail. 2015 Nov;8(6):1115-22 PMC4651836

Kumar M, Govindan S, Zhang M, Khairallah RJ, Martin JL, Sadayappan S, deTombe PP.

Cardiac myosin-binding protein C and Troponin-I phosphorylation independently modulate myofilament length-dependent activation. J Biol Chem. 2015 Dec 4;290(49):29241-9 PMC4705930

Tong CW, WuX, LiuY, Rosas PC, Sadayappan S, Hudmon A, Muthuchamy M, Powers PA, Valdivia HH, Moss RL.

Phosphoregulation of cardiac inotropy via myosin binding protein-C during increased pacing frequency or β1-adrenergic stimulation. Circ Heart Fail. 2015 May;8(3):595- 604PMC4439328

Kuster DW, Govindan S, Springer TI, Martin JL, Finley NL, Sadayappan S.

A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction. J Biol Chem. 2015 Feb 27;290(9):5855-67 PMC4342493

Barefield D, Kumar M, Gorham J, Seidman JG, Seidman CE, deTombe PP, Sadayappan S.

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice. J Mol Cell Cardiol. 2015 Feb;79:234-43PMC4642280

Lee K, Harris SP, Sadayappan S, Craig R.

Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM. J Mol Biol. 2015 Jan 30;427(2):274-86PMC4297556

Wang L, Sadayappan S, Kawai M.

Cardiac myosin binding protein-C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner. PLoS One. 2014 Nov 24;9(11):e113417PMC4242647

Simon JN, Chowdhury SA, Warren CM, Sadayappan S, Wieczorek DF, Solaro RJ, Wolska BM.

Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation. Basic Res Cardiol. 2014;109(6):445PMC4440670

Wilson K, Guggilam A, West TA, Zhang X, Trask AJ, Cismowski MJ, deTombe P, Sadayappan S, Lucchesi PA.

Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure. Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1605-17PMC4255015

Helms AS, Davis FM, Coleman D, Bartolone SN, Glazier AA, Pagani F, Yob JM, Sadayappan S, Pedersen E, Lyons R, WestfallMV, Jones R, RussellMW, Day SM.

Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy. Circ Cardiovasc Genet. 2014 Aug;7(4):434-43PMC4254656

Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, Möllmann H.

Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction. PLoS One. 2014 Jun 3;9(6):e98456PMC4043649

Lynch TL, Sadayappan S.

Surviving the infarct: A profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium. Proteomics Clin Appl. 2014 Aug;8(7-8):569-77 PMC4162529

Wang L, Ji X, Barefield D, Sadayappan S, Kawai M.

Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner. Biophys J. 2014 Mar 4;106(5):1112-22 PMC4026776

Alves ML, Dias FA, Gaffin RD, Simon JN, Montminy EM, Biesiadecki BJ, Hinken AC, Warren CM, Utter MS, Davis RT 3rd, Sadayappan S, Robbins J, Wieczorek DF, Solaro RJ, Wolska BM.

Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins. Circ Cardiovasc Genet. 2014 Apr;7(2):132-43PMID: 24585742

Haynes P, Nava KE, Lawson BA, Chung CS, Mitov MI, Campbell SG, Stromberg AJ, Sadayappan S, Bonnell MR, Hoopes CW, Campbell KS.

Transmural heterogeneity of cellular level power output is reduced in human heart failure. J Mol Cell Cardiol. 2014 Jul;72:1-8 PMC4037376

Witayavanitkul N, AitMou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, deTombe PP, Sadayappan S.

Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium. J Biol Chem. 2014 Mar 28;289(13):8818-27 PMC3979389

Barefield D, Kumar M, deTombe PP, Sadayappan S.

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H807-15 PMC3949045

Kuster DW, Cardenas-Ospina A, Miller L, Liebetrau C, Troidl C, Nef HM, Möllmann H, Hamm CW, Pieper KS, Mahaffey KW, Kleiman NS, Stuyvers BD, Marian AJ, Sadayappan S.

Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury. Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H547-56 PMC3920245

Kuster DW, Sadayappan S.

MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation. Pflugers Arch. 2014 Feb;466(2):207-13. doi: 10.1007/s00424-013-1417-7 PMC3946836

Gao X, Lin B, Sadayappan S, Patel TB.

Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis. Mol Pharmacol. 2014 Feb;85(2):357-67 PMC3913359

Sadayappan S, deTombe PP.

Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series. Pflugers Arch. 2014 Feb;466(2):195-200. doi: 10.1007/s00424-013-1396-8 PMC3946865

Khairallah RJ, Sadayappan S.

Finding the missing link: disulfide-containing proteins via a high-throughput proteomics approach. Proteomics. 2013 Nov;13(22):3245-6PMC3923460

Guillory AN, Yin X, Wijaya CS, DiazDiaz AC, Rababa'h A, Singh S, Atrooz F, Sadayappan S, McConnell BK.

Enhanced cardiac function in Gravin mutant mice involves alterations in the β- adrenergic receptor signaling cascade. PLoS One. 2013 Sep 18;8(9):e74784 PMC3776749

Kuster DW, Barefield D, Govindan S, Sadayappan S.

A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay. J Vis Exp. 2013 Aug 8;(78) PMC3854717

Lin B, Govindan S, Lee K, Zhao P, Han R, Runte KE, Craig R, Palmer BM, Sadayappan S.

Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function. PLoS One. 2013 Jul 31;8(7):e69671 PMC3729691

Govindan S, Kuster DW, Lin B, Kahn DJ, Jeske WP, Walenga JM, Leya F, Hoppensteadt D, Fareed J, Sadayappan S.

Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac- specific biomarker of myocardial infarction. Am J Cardiovasc Dis. 2013 Jun 10;3(2):60-70 PMC3683403

Hwang H, Robinson D, Rogers JB, Stevenson TK, Lang SE, Sadayappan S, Day SM, Sivaramakrishnan S, Westfall MV.

Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function. Sci Rep. 2013;3:1971 PMC3679501

Jin CZ, Jang JH, Kim HJ, Wang Y, Hwang IC, Sadayappan S, Park BM, Kim SH, Jin ZH, Seo EY, Kim KH, Kim YJ, Kim SJ, Zhang YH.

Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart. J Mol Cell Cardiol. 2013 Jul;60:107-15PMID: 23624088

Kuster DW, Sequeira V, Najafi A, Boontje NM, Wijnker PJ, Witjas-Paalberends ER, Marston SB, DosRemedios CG, Carrier L, Demmers JA, Redwood C, Sadayappan S, vanderVelden J.

GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human. Circ Res. 2013 Feb 15;112(4):633-9 PMC3595322

Sequeira V, Wijnker PJ, Nijenkamp LL, Kuster DW, Najafi A, Witjas-Paalberends ER, Regan JA, Boontje N, TenCate FJ, Germans T, Carrier L, Sadayappan S, vanSlegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, DosRemedios C, Stienen GJ, Ho CY, Michels M, vanderVelden J.

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. Circ Res. 2013 May 24;112(11):1491-505PMC3675884

Guggilam A, Hutchinson KR, West TA, Kelly AP, Galantowicz ML, Davidoff AJ, Sadayappan S, Lucchesi PA.

In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume- overload heart failure. J Mol Cell Cardiol. 2013 Apr;57:47-58PMC3696990

Sadayappan S, deTombe PP.

Cardiac myosin binding protein-C: redefining its structure and function. Biophys Rev. 2012 Jun 1;4(2):93-106PMC3374655

Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh AK, Kishore R.

Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB. Circulation. 2012 Jul 24;126(4):418-29 PMC3422741

Dirkx E, Cazorla O, Schwenk RW, Lorenzen-Schmidt I, Sadayappan S, VanLint J, Carrier L, vanEys GJ, Glatz JF, Luiken JJ.

Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315. Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H323-31 PMID: 22636676

Hinken AC, Hanft LM, Scruggs SB, Sadayappan S, Robbins J, Solaro RJ, McDonald KS.

Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A. J Muscle Res Cell Motil. 2012 Dec;33(6):439-48 PMC3568763

Govindan S, Sarkey J, Ji X, Sundaresan NR, Gupta MP, deTombe PP, Sadayappan S.

Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. J Muscle Res Cell Motil. 2012 May;33(1):17-30 PMC3368277

Sadayappan S.

Cardiac myosin binding protein-C: a potential early-stage, cardiac-specific biomarker of ischemia-reperfusion injury. Biomark Med. 2012 Feb;6(1):69-72PMC3339268

Howarth JW, Ramisetti S, Nolan K, Sadayappan S, Rosevear PR.

Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain. J Biol Chem. 2012 Mar 9;287(11):8254-62PMC3318737

vanDijk SJ, Paalberends ER, Najafi A, Michels M, Sadayappan S, Carrier L, Boontje NM, Kuster DW, vanSlegtenhorst M, Dooijes D, dosRemedios C, tenCate FJ, Stienen GJ, vanderVelden J.

Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function. Circ Heart Fail. 2012 Jan;5(1):36-46 PMID: 22178992

Weith A, Sadayappan S, Gulick J, Previs MJ, Vanburen P, Robbins J, Warshaw DM.

Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. J Mol Cell Cardiol. 2012 Jan;52(1):219-27 PMC3246064

Govindan S, McElligott A, Muthusamy S, Nair N, Barefield D, Martin JL, Gongora E, Greis KD, Luther PK, Winegrad S, Henderson KK, Sadayappan S.

Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction. J Mol Cell Cardiol. 2012 Jan;52(1):154-64 PMC3246118

Palmer BM, Sadayappan S, Wang Y, Weith AE, Previs MJ, Bekyarova T, Irving TC, Robbins J, Maughan DW.

Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophys J. 2011 Oct 5;101(7):1661-9 PMC3183797

Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J.

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 2011 Jul 8;109(2):141-50 PMC3132348

Cuello F, Bardswell SC, Haworth RS, Ehler E, Sadayappan S, Kentish JC, Avkiran M.

Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation. J Biol Chem. 2011 Feb 18;286(7):5300-10 PMC3037642

Copeland O, Sadayappan S, Messer AE, Steinen GJ, vanderVelden J, Marston SB.

Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle. J Mol Cell Cardiol. 2010 Dec;49(6):1003-11 PMID: 20850451

Senapathy P, Bhasi A, Mattox J, Dhandapany PS, Sadayappan S.

Targeted genome-wide enrichment of functional regions. PLoS One. 2010 Jun 16;5(6):e11138 PMC2886846

Bardswell SC, Cuello F, Rowland AJ, Sadayappan S, Robbins J, Gautel M, Walker JW, Kentish JC, Avkiran M.

Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling. J Biol Chem. 2010 Feb 19;285(8):5674-82 PMC2820795

Barefield D, Sadayappan S.

Phosphorylation and function of cardiac myosin binding protein-C in health and disease. J Mol Cell Cardiol. 2010 May;48(5):866-75PMID:19962384

From Dr. Sadayappan’s postdoctoral projects :

Nicolaou P, Rodriguez P, Ren X, Zhou X, Qian J, Sadayappan S, Mitton B, Pathak A, Robbins J, Hajjar RJ, Jones K, Kranias EG.

Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circ Res. 2009 Apr 24;104(8):1012-20 PMC2752882

Sadayappan S,Gulick J, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, Robbins J.

Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation. 2009 Mar 10;119(9):1253-62 PMC2656413

Dhandapany PS, Sadayappan S, Xue Y, Powell GT, Rani DS, Nallari P, Rai TS, Khullar M, Soares P, Bahl A, Tharkan JM, Vaideeswar P, Rathinavel A, Narasimhan C, Ayapati DR, Ayub Q, Mehdi SQ, Oppenheimer S, Richards MB, Price AL, Patterson N, Reich D, Singh L, Tyler-Smith C, Thangaraj K.

A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nat Genet. 2009 Feb;41(2):187-91 PMC2697598

Sadayappan S, Robbins J.

The death of transcriptional chauvinism in the control and regulation of cardiac contractility. Ann N Y Acad Sci. 2008 Mar;1123:1-9 PMID: 18375572

Nagayama T, Takimoto E, Sadayappan S, Mudd JO, Seidman JG, Robbins J, Kass DA.

Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation. Circulation. 2007 Nov 20;116(21):2399-408 PMID: 17984378

Yasuda S, Coutu P, Sadayappan S, Robbins J, Metzger JM.

Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circ Res. 2007 Aug 17;101(4):377-86 PMID: 17615373

Sadayappan S, Finley N, Howarth JW, Osinska H, Klevitsky R, Lorenz JN, Rosevear PR, Robbins J.

Role of the acidic N' region of cardiac troponin I in regulating myocardial function. FASEB J. 2008 Apr;22(4):1246-57 PMC2362400

Krenz M, Sadayappan S, Osinska HE, Henry JA, Beck S, Warshaw DM, Robbins J.

Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart. J Biol Chem. 2007 Aug 17;282(33):24057-64 PMID:17575272

Dhandapany PS, Sadayappan S, Vanniarajan A, Karthikeyan B, Nagaraj C, Gowrishankar K, Selvam GS, Singh L, Thangaraj K.

Novel mitochondrial DNA mutations implicated in Noonan syndrome. Int J Cardiol. 2007 Aug 21;120(2):284-5 PMID: 17092585

Sadayappan S, Osinska H, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, Seidman CE, Seidman JG, Robbins J.

Cardiac myosin binding protein C phosphorylation is cardioprotective. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16918-23 PMC1636554

Wang H, Grant JE, Doede CM, Sadayappan S, Robbins J, Walker JW.

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. J Mol Cell Cardiol. 2006 Nov;41(5):823-33 PMID: 17010989

Sadayappan S, Gulick J, Osinska H, Martin LA, Hahn HS, Dorn GW 2nd, Klevitsky R, Seidman CE, Seidman JG, Robbins J.

Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ Res. 2005 Nov 25;97(11):1156-63 PMC1343494

Annapoorani P, Dhandapany PS, Sadayappan S, Ramasamy S, Rathinavel A, Selvam GS.

Cardiac isoform of alpha-2 macroglobulin-a new biomarker for myocardial infarcted diabetic patients. Atherosclerosis. 2006 May;186(1):173-6 PMID:16102773

Sanbe A, James J, Tuzcu V, Nas S, Martin L, Gulick J, Osinska H, Sakthivel S, Klevitsky R, Ginsburg KS, Bers DM, Zinman B, Lakatta EG, Robbins J.

Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy. Circulation. 2005 May 10;111(18):2330-8 PMC1314982

Sakthivel S, Finley NL, Rosevear PR, Lorenz JN, Gulick J, Kim S, VanBuren P, Martin LA, Robbins J.

In vivo and in vitro analysis of cardiac troponin I phosphorylation. J Biol Chem. 2005 Jan 7;280(1):703-14 PMID: 15507454

From Dr. Sadayappan’s PhD projects :

Waldmüller S, Sakthivel S, Saadi AV, Selignow C, Rakesh PG, Golubenko M, Joseph PK, Padmakumar R, Richard P, Schwartz K, Tharakan JM, Rajamanickam C, Vosberg HP.

Novel deletions in MYH7 and MYBPC3 identified in Indian families with familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2003 Jun;35(6):623-36 PMID: 12788380

Sakthivel S,Vosberg HP, Rajamanickam C.

Oligonucleotide ligation assay for rapid and sensitive identification of carriers of a missense mutation in the cardiac -myosin heavy chain gene causing hypertrophic cardiomyopathy in an Indian family. Current Science. 2001; 80 (12):1588-1592.

Rajamanickam C, Sakthivel S, Babu GJ, Lottspeich F, Kadenbach B.

Cardiac isoform of alpha-2 macroglobulin, a novel serum protein, may induce cardiac hypertrophy in rats. Basic Res Cardiol. 2001; 96: 23-33 PMID: 11215529

Chakarova C, Wehnert MS, Uhl K, Sakthivel S,Vosberg HP, Ven PFM and Fürst DO.

Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family. Hum Genet. 2000; 107:597-611 PMID: 11153914

Sakthivel S, Joseph PK, Tharakan JM, Vosberg HP, Rajamanickam C.

A novel missense mutation (R712L) adjacent to the "active thiol" region of the cardiac -myosin heavy chain gene causing hypertrophic cardiomyopathy in an Indian family. Hum Mutat. 1999; 15(3): 298-299 PMID: 10679957

Rajamanickam C, Sakthivel S, Joseph PK, Janarthanan RA.

A novel serum protein of molecular weight 182 kDa: A molecular marker for an early detection of increased LVM mass in patients with cardiac hypertrophy. J Cardiovasc Risk. 1998; 5(6): 335-338 PMID: 9920006

Sakthivel S, Renuga G, Ravindranath M, Shanmugam J, Rajamanickam C.

Impact of cardiac hypertrophy specific serum protein of molecular weight 182 kDa protein in viral induced myocarditis. Indian J. Virology. 1997; 13(2): 85-90.

Sakthivel S. and Rajamanickam C.

Molecular aspects of cardiac hypertrophy. BioBytes. 1993; 1:11-12.

For queries and opportunities, Please Contact :

Sakthivel Sadayappan, PhD, MBA
Professor of Internal Medicine
Associate Chairman for Basic Research
Department of Internal Medicine
Director of Heart Branch of the Heart, Lung and Vascular Institute
Division of Cardiovascular Health and Disease
University of Cincinnati, College of Medicine
Cardiovascular Center, Rm 4935
231 Albert Sabin Way
Cincinnati, OH 45267-0542, USA
Phone : +1 513-558-7498
Email : sadayasl@ucmail.uc.edu

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