From University of Cincinnati since Aug 2016 :

Lin BL, Song T, Sadayappan S.

Myofilaments: Movers and Rulers of the Sarcomere Compr Physiol. 2017 Mar 16;7(2):675-692 PMID : 28333386

Barefield DY, Lynch TL 4th, Jagadeesan A, Sanagala T, Sadayappan S.

High-Throughputdiagnosticassayforahighlyprevalentcardiomyopathy-associatedMYBPC3 variant. JMolBiomarkDiagn. 2016 Nov;7(6) PMC5160998

Lynch TL 4th, Ismahil MA, Jegga AG, Zilliox MJ, Troidl C, Prabhu SD, Sadayappan S.

CardiacinflammationingeneticdilatedcardiomyopathycausedbyMYBPC3 mutation. JMolCellCardiol. 2016 Dec 10;102:83-93 PMID: 27955979

Kraker J, Viswanathan SK, Knöll R, Sadayappan S.

RecentAdvancesintheMoleculargeneticsoffamilialhypertrophiccardiomyopathyinSouthAsianDescendants. FrontPhysiol. 2016 Oct 28;7:499 PMC5083855

From Loyola University Chicago since Sep 2009 :

Hoffman MP, Taylor EN, Aninwene GE 2nd, Sadayappan S, Gilbert RJ.

AssessingthemultiscalearchitectureofmusculartissuewithQ-spacemagneticresonanceimaging: Review. MicroscResTech. 2016 Oct 2. doi: 10.1002/jemt.22777. [Epubaheadofprint] PMID: 27696640

Lipps C, Nguyen JH, Pyttel L, Lynch TL 4th, Liebetrau C, Aleshcheva G, Voss S,Dörr O, NefHM, Möllmann H, Hamm CW, Sadayappan S, Troidl C.

N-terminalfragmentofcardiacmyosinbindingprotein-Ctriggerspro-inflammatoryresponsesinvitro.JMolCellCardiol. 2016 Oct;99:47-56 PMC5107329

Taylor EN, Hoffman MP, Barefield DY, Aninwene GE 2nd, Abrishamchi AD, Lynch TL 4th, Govindan S, Osinska H, Robbins J, Sadayappan S, Gilbert RJ.

Alterationsinmulti-scalecardiacarchitectureinassociationwithphosphorylationofmyosinbindingprotein-C. JAmHeartAssoc. 2016 Mar 15;5(3):e002836 PMC4943261

Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, vanderVelden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F.

S-glutathiolationimpairsphosphoregulationandfunctionofcardiacmyosin-bindingproteinCinhumanheartfailure. FASEBJ. 2016 May;30(5):1849-64 PMC4836368

Sivaguru M, Fried G, Sivaguru BS, Sivaguru VA, LuX, Choi KH, Saif MT, Lin B, Sadayappan S.

Cardiacmuscleorganizationrevealedin 3-Dbyimagingwhole-mountmouseheartsusingtwo-photonfluorescenceandconfocalmicroscopy.Biotechniques. 2015 Nov 1;59(5):295-308PMID:26554507

Lynch TL 4th, Sivaguru M, Velayutham M, Cardounel AJ, Michels M, Barefield D,Govindan S, dosRemedios C, vander Velden J, Sadayappan S.

OxidativeStressinDilatedcardiomyopathycausedbyMYBPC3 mutation. OxidMedCellLongev.2015;2015:424751 PMC4609873

Thoonen R, Giovanni S, Govindan S, Lee DI, Wang GR, Calamaras TD, Takimoto E, Kass DA, Sadayappan S, Blanton RM.

MolecularScreenIdentifiesCardiacMyosin-BindingProtein-CasaProteinKinaseG-IαSubstrate. CircHeartFail.2015 Nov;8(6):1115-22 PMC4651836

Kumar M, Govindan S, Zhang M, Khairallah RJ, Martin JL, Sadayappan S, deTombe PP.

Cardiacmyosin-bindingproteinCandTroponin-I phosphorylation independentlymodulatemyofilamentlength-dependentactivation. JBiolChem. 2015Dec 4;290(49):29241-9 PMC4705930

Tong CW, WuX, LiuY, Rosas PC, Sadayappan S, Hudmon A, Muthuchamy M, Powers PA, Valdivia HH, Moss RL.

Phosphoregulationofcardiacinotropyviamyosinbindingprotein-Cduringincreasedpacingfrequencyorβ1-adrenergicstimulation.CircHeartFail. 2015 May;8(3):595-604 PMC4439328

Kuster DW, Govindan S, Springer TI, Martin JL, Finley NL, Sadayappan S.

Ahypertrophiccardiomyopathy-associatedMYBPC3 mutationcommoninpopulationsofSouthAsiandescentcausescontractiledysfunction. JBiolChem. 2015 Feb 27;290(9):5855-67 PMC4342493

Barefield D, Kumar M, Gorham J, Seidman JG, Seidman CE, deTombe PP, Sadayappan S.

HaploinsufficiencyofMYBPC3 exacerbatesthedevelopmentofhypertrophiccardiomyopathyinheterozygousmice. JMolCellCardiol. 2015Feb;79:234-43PMC4642280

Lee K, Harris SP, Sadayappan S, Craig R.

OrientationofmyosinbindingproteinCinthecardiacmusclesarcomeredeterminedbydomain-specificimmuno-EM. JMolBiol. 2015 Jan 30;427(2):274-86PMC4297556

Wang L, Sadayappan S, Kawai M.

Cardiacmyosinbindingprotein-Cphosphorylationaffectscross-bridgecycle'selementarystepsinasite-specificmanner. PLoSOne. 2014 Nov 24;9(11):e113417PMC4242647

Simon JN, Chowdhury SA, Warren CM, Sadayappan S, Wieczorek DF, Solaro RJ, Wolska BM.

Ceramide-mediateddepressionincardiomyocytecontractilitythroughPKCactivationandmodulationofmyofilamentproteinphosphorylation. BasicResCardiol. 2014;109(6):445PMC4440670

Wilson K, Guggilam A, West TA, Zhang X, Trask AJ, Cismowski MJ, deTombe P, Sadayappan S, Lucchesi PA.

Effectsofamyofilamentcalciumsensitizeronleftventricularsystolicanddiastolicfunctioninratswithvolumeoverloadheartfailure. AmJPhysiolHeartCircPhysiol. 2014 Dec 1;307(11):H1605-17PMC4255015

Helms AS, Davis FM, Coleman D, Bartolone SN, Glazier AA, Pagani F, Yob JM, Sadayappan S, Pedersen E, Lyons R, WestfallMV, Jones R, RussellMW, Day SM.

Sarcomeremutation-specificexpressionpatternsinhumanhypertrophiccardiomyopathy. CircCardiovascGenet. 2014 Aug;7(4):434-43PMC4254656

Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, Möllmann H.

Shamsurgeryandinter-individualheterogeneityaremajordeterminantsofmonocytesubsetkineticsinamousemodelofmyocardialinfarction. PLoSOne. 2014 Jun 3;9(6):e98456PMC4043649

Lynch TL, Sadayappan S.

Survivingtheinfarct: Aprofileofcardiacmyosinbindingprotein-Cpathogenicity, diagnosticutility, andproteomicsintheischemicmyocardium. ProteomicsClinAppl. 2014 Aug;8(7-8):569-77 PMC4162529

Wang L, Ji X, Barefield D, Sadayappan S, Kawai M.

PhosphorylationofcMyBP-Caffectscontractilemechanismsinasite-specificmanner. BiophysJ. 2014 Mar4;106(5):1112-22 PMC4026776

Alves ML, Dias FA, Gaffin RD, Simon JN, Montminy EM, Biesiadecki BJ, Hinken AC, Warren CM, Utter MS, Davis RT 3rd, Sadayappan S, Robbins J, Wieczorek DF, Solaro RJ, Wolska BM.

DesensitizationofmyofilamentstoCa2+ asatherapeutictargetforhypertrophiccardiomyopathywithmutationsinthinfilamentproteins. CircCardiovascGenet. 2014 Apr;7(2):132-43 PMID: 24585742

Haynes P, Nava KE, Lawson BA, Chung CS, Mitov MI, Campbell SG, Stromberg AJ, Sadayappan S, Bonnell MR, Hoopes CW, Campbell KS.

Transmuralheterogeneityofcellularlevelpoweroutputisreducedinhumanheartfailure. JMolCellCardiol. 2014 Jul;72:1-8 PMC4037376

Witayavanitkul N, AitMou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, deTombe PP, Sadayappan S.

Myocardialinfarction-inducedN-terminalfragmentofcardiacmyosin-bindingproteinC (cMyBP-C) impairsmyofilamentfunctioninhumanmyocardium. JBiolChem. 2014 Mar 28;289(13):8818-27 PMC3979389

Barefield D, Kumar M, deTombe PP, Sadayappan S.

ContractiledysfunctioninamousemodelexpressingaheterozygousMYBPC3 mutationassociatedwithhypertrophiccardiomyopathy. AmJPhysiolHeartCircPhysiol. 2014Mar;306(6):H807-15 PMC3949045

Kuster DW, Cardenas-Ospina A, Miller L, Liebetrau C, Troidl C, Nef HM, Möllmann H, Hamm CW, Pieper KS, Mahaffey KW, Kleiman NS, Stuyvers BD, Marian AJ, Sadayappan S.

Releasekineticsofcirculatingcardiacmyosinbindingprotein-Cfollowingcardiacinjury. AmJPhysiolHeartCircPhysiol. 2014 Feb15;306(4):H547-56 PMC3920245

Kuster DW, Sadayappan S.

MYBPC3'salternateending: consequencesandtherapeuticimplicationsofahighlyprevalent 25 bpdeletionmutation. PflugersArch. 2014 Feb;466(2):207-13. doi: 10.1007/s00424-013-1417-7 PMC3946836

Gao X, Lin B, Sadayappan S, Patel TB.

InteractionsbetweentheregulatorysubunitoftypeIproteinkinaseAandp90 ribosomalS6 kinase1 regulatecardiomyocyteapoptosis. MolPharmacol. 2014 Feb;85(2):357-67 PMC3913359

Sadayappan S, deTombe PP.

Cardiacmyosinbindingprotein-Casacentraltargetofcardiacsarcomeresignaling: aspecialminireviewseries. PflugersArch. 2014 Feb;466(2):195-200. doi: 10.1007/s00424-013-1396-8 PMC3946865

Khairallah RJ, Sadayappan S.

Findingthemissinglink: disulfide-containingproteinsviaahigh-throughputproteomicsapproach. Proteomics. 2013Nov;13(22):3245-6PMC3923460

Guillory AN, Yin X, Wijaya CS, DiazDiaz AC, Rababa'h A, Singh S, Atrooz F, Sadayappan S, McConnell BK.

EnhancedcardiacfunctioninGravinmutantmiceinvolvesalterationsintheβ-adrenergicreceptorsignalingcascade. PLoSOne.2013 Sep 18;8(9):e74784 PMC3776749

Kuster DW, Barefield D, Govindan S, Sadayappan S.

Asensitiveandspecificquantitationmethodfordeterminationofserumcardiacmyosinbindingprotein-Cbyelectrochemiluminescenceimmunoassay. JVisExp. 2013 Aug 8;(78) PMC3854717

Lin B, Govindan S, Lee K, Zhao P, Han R, Runte KE, Craig R, Palmer BM, Sadayappan S.

Cardiacmyosinbindingprotein-Cplaysnoregulatoryroleinskeletalmusclestructureandfunction. PLoSOne. 2013 Jul 31;8(7):e69671 PMC3729691

Govindan S, Kuster DW, Lin B, Kahn DJ, Jeske WP, Walenga JM, Leya F, Hoppensteadt D, Fareed J, Sadayappan S.

Increaseincardiacmyosinbindingprotein-Cplasmalevelsisasensitiveandcardiac-specificbiomarkerofmyocardialinfarction. AmJCardiovascDis. 2013 Jun 10;3(2):60-70 PMC3683403

Hwang H, Robinson D, Rogers JB, Stevenson TK, Lang SE, Sadayappan S, Day SM, Sivaramakrishnan S, Westfall MV.

AgonistactivatedPKCβIItranslocationandmodulationofcardiacmyocytecontractilefunction. SciRep. 2013;3:1971 PMC3679501

Jin CZ, Jang JH, Kim HJ, Wang Y, Hwang IC, Sadayappan S, Park BM, Kim SH, Jin ZH, Seo EY, Kim KH, Kim YJ, Kim SJ, Zhang YH.

MyofilamentCa2+ desensitizationmediatespositivelusitropiceffectofneuronalnitricoxidesynthaseinleftventricularmyocytesfrommurinehypertensiveheart. JMolCellCardiol. 2013 Jul;60:107-15 PMID: 23624088

Kuster DW, Sequeira V, Najafi A, Boontje NM, Wijnker PJ, Witjas-Paalberends ER, Marston SB, DosRemedios CG, Carrier L, Demmers JA, Redwood C, Sadayappan S, vanderVelden J.

GSK3βphosphorylatesnewlyidentifiedsiteintheproline-alanine-richregionofcardiacmyosin-bindingproteinCandalterscross-bridgecyclingkineticsinhuman.CircRes. 2013 Feb15;112(4):633-9 PMC3595322

Sequeira V, Wijnker PJ, Nijenkamp LL, Kuster DW, Najafi A, Witjas-Paalberends ER, Regan JA, Boontje N, TenCate FJ, Germans T, Carrier L, Sadayappan S, vanSlegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, DosRemedios C, Stienen GJ, Ho CY, Michels M, vanderVelden J.

Perturbedlength-dependentactivationinhumanhypertrophiccardiomyopathywithmissensesarcomericgenemutations. CircRes. 2013 May 24;112(11):1491-505 PMC3675884

Guggilam A, Hutchinson KR, West TA, Kelly AP, Galantowicz ML, Davidoff AJ, Sadayappan S, Lucchesi PA.

Invivoandinvitrocardiacresponsestobeta-adrenergicstimulationinvolume-overloadheartfailure. JMolCellCardiol.2013 Apr;57:47-58 PMC3696990

Sadayappan S, deTombe PP.

Cardiacmyosinbindingprotein-C: redefiningitsstructureandfunction. BiophysRev. 2012 Jun 1;4(2):93-106 PMC3374655

Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh AK, Kishore R.

Interleukin-10 treatmentattenuatespressureoverload-inducedhypertrophicremodelingandimprovesheartfunctionviasignaltransducersandactivatorsoftranscription 3-dependentinhibitionofnuclearfactor-κB. Circulation. 2012 Jul24;126(4):418-29 PMC3422741

Dirkx E, Cazorla O, Schwenk RW, Lorenzen-Schmidt I, Sadayappan S, VanLint J, Carrier L, vanEys GJ, Glatz JF, Luiken JJ.

ProteinkinaseDincreasesmaximalCa2+-activatedtensionofcardiomyocytecontractionbyphosphorylationofcMyBP-C-Ser315. AmJPhysiolHeartCircPhysiol. 2012 Aug 1;303(3):H323-31 PMID: 22636676

Hinken AC, Hanft LM, Scruggs SB, Sadayappan S, Robbins J, Solaro RJ, McDonald KS.

ProteinkinaseCdepressescardiacmyocytepoweroutputandattenuatesmyofilamentresponsesinducedbyproteinkinaseA. JMuscleResCellMotil. 2012Dec;33(6):439-48 PMC3568763

Govindan S, Sarkey J, Ji X, Sundaresan NR, Gupta MP, deTombe PP, Sadayappan S.

PathogenicpropertiesoftheN-terminalregionofcardiacmyosinbindingprotein-Cinvitro. JMuscleResCellMotil. 2012 May;33(1):17-30 PMC3368277

Sadayappan S.

Cardiacmyosinbindingprotein-C: apotentialearly-stage,cardiac-specificbiomarkerofischemia-reperfusioninjury. BiomarkMed. 2012Feb;6(1):69-72 PMC3339268

Howarth JW, Ramisetti S, Nolan K, Sadayappan S, Rosevear PR.

Structuralinsightintouniquecardiacmyosin-bindingprotein-Cmotif: apartiallyfoldeddomain. JBiolChem. 2012 Mar 9;287(11):8254-62 PMC3318737

vanDijk SJ, Paalberends ER, Najafi A, Michels M, Sadayappan S, Carrier L, Boontje NM, Kuster DW, vanSlegtenhorst M, Dooijes D, dosRemedios C, tenCate FJ, Stienen GJ, vanderVelden J.

Contractiledysfunctionirrespectiveofthemutantproteininhumanhypertrophiccardiomyopathywithnormalsystolicfunction. CircHeartFail. 2012 Jan;5(1):36-46 PMID: 22178992

Weith A, Sadayappan S, Gulick J, Previs MJ, Vanburen P, Robbins J, Warshaw DM.

Uniquesinglemoleculebindingofcardiacmyosinbindingprotein-Ctoactinandphosphorylation-dependentinhibitionofactomyosinmotilityrequires 17 aminoacidsofthemotifdomain. JMolCellCardiol. 2012 Jan;52(1):219-27 PMC3246064

Govindan S, McElligott A, Muthusamy S, Nair N, Barefield D, Martin JL, Gongora E, Greis KD, Luther PK, Winegrad S, Henderson KK, Sadayappan S.

Cardiacmyosinbindingprotein-Cisapotentialdiagnosticbiomarkerformyocardialinfarction. JMolCellCardiol. 2012 Jan;52(1):154-64 PMC3246118

Palmer BM, Sadayappan S, Wang Y, Weith AE, Previs MJ, Bekyarova T, Irving TC, Robbins J, Maughan DW.

RolesforcardiacMyBP-Cinmaintainingmyofilamentlatticerigidityandprolongingmyosincross-bridgelifetime. BiophysJ. 2011 Oct5;101(7):1661-9 PMC3183797

Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J.

AcriticalfunctionforSer-282 incardiacMyosinbindingprotein-Cphosphorylationandcardiacfunction. CircRes. 2011 Jul 8;109(2):141-50 PMC3132348

Cuello F, Bardswell SC, Haworth RS, Ehler E, Sadayappan S, Kentish JC, Avkiran M.

Novelroleforp90 ribosomalS6 kinaseintheregulationofcardiacmyofilamentphosphorylation. JBiolChem. 2011 Feb 18;286(7):5300-10 PMC3037642

Copeland O, Sadayappan S, Messer AE, Steinen GJ, vanderVelden J, Marston SB.

Analysisofcardiacmyosinbindingprotein-Cphosphorylationinhumanheartmuscle. JMolCellCardiol. 2010 Dec;49(6):1003-11 PMID: 20850451

Senapathy P, Bhasi A, Mattox J, Dhandapany PS, Sadayappan S.

Targetedgenome-wideenrichmentoffunctionalregions. PLoSOne. 2010 Jun 16;5(6):e11138 PMC2886846

Bardswell SC, Cuello F, Rowland AJ, Sadayappan S, Robbins J, Gautel M, Walker JW, Kentish JC, Avkiran M.

DistinctsarcomericsubstratesareresponsibleforproteinkinaseD-mediatedregulationofcardiacmyofilamentCa2+ sensitivityandcross-bridgecycling. JBiolChem. 2010 Feb 19;285(8):5674-82 PMC2820795

Barefield D, Sadayappan S.

Phosphorylationandfunctionofcardiacmyosinbindingprotein-Cinhealthanddisease. JMolCellCardiol. 2010May;48(5):866-75 PMID:19962384

From Dr. Sadayappan’s postdoctoral projects :

Nicolaou P, Rodriguez P, Ren X, Zhou X, Qian J, Sadayappan S, Mitton B, Pathak A, Robbins J, Hajjar RJ, Jones K, Kranias EG.

Inducibleexpressionofactiveproteinphosphatase-1 inhibitor-1 enhancesbasalcardiacfunctionandprotectsagainstischemia/reperfusioninjury. CircRes. 2009 Apr24;104(8):1012-20 PMC2752882

Sadayappan S,Gulick J, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, Robbins J.

Cardiacmyosinbindingprotein-Cphosphorylationina {beta}-myosinheavychainbackground. Circulation. 2009 Mar 10;119(9):1253-62 PMC2656413

Dhandapany PS, Sadayappan S, Xue Y, Powell GT, Rani DS, Nallari P, Rai TS, Khullar M, Soares P, Bahl A, Tharkan JM, Vaideeswar P, Rathinavel A, Narasimhan C, Ayapati DR, Ayub Q, Mehdi SQ, Oppenheimer S, Richards MB, Price AL, Patterson N, Reich D, Singh L, Tyler-Smith C, Thangaraj K.

AcommonMYBPC3 (cardiacmyosinbindingproteinC) variantassociatedwithcardiomyopathiesinSouthAsia. NatGenet. 2009 Feb;41(2):187-91 PMC2697598

Sadayappan S, Robbins J.

Thedeathoftranscriptionalchauvinisminthecontrolandregulationofcardiaccontractility. AnnNYAcadSci. 2008Mar;1123:1-9 PMID: 18375572

Nagayama T, Takimoto E, Sadayappan S, Mudd JO, Seidman JG, Robbins J, Kass DA.

Controlofinvivoleftventricular [correction] contraction/relaxationkineticsbymyosinbindingproteinC: proteinkinaseAphosphorylationdependentandindependentregulation. Circulation. 2007 Nov 20;116(21):2399-408 PMID: 17984378

Yasuda S, Coutu P, Sadayappan S, Robbins J, Metzger JM.

CardiactransgenicandgenetransferstrategiesconvergetosupportanimportantrolefortroponinIinregulatingrelaxationincardiacmyocytes. CircRes. 2007 Aug17;101(4):377-86 PMID: 17615373

Sadayappan S, Finley N, Howarth JW, Osinska H, Klevitsky R, Lorenz JN, Rosevear PR, Robbins J.

RoleoftheacidicN' regionofcardiactroponinIinregulatingmyocardialfunction. FASEBJ. 2008 Apr;22(4):1246-57 PMC2362400

Krenz M, Sadayappan S, Osinska HE, Henry JA, Beck S, Warshaw DM, Robbins J.

Distributionandstructure-functionrelationshipofmyosinheavychainisoformsintheadultmouseheart. JBiolChem. 2007 Aug 17;282(33):24057-64 PMID:17575272

Dhandapany PS, Sadayappan S, Vanniarajan A, Karthikeyan B, Nagaraj C, Gowrishankar K, Selvam GS, Singh L, Thangaraj K.

NovelmitochondrialDNAmutationsimplicatedinNoonansyndrome. IntJCardiol. 2007 Aug 21;120(2):284-5 PMID: 17092585

Sadayappan S, Osinska H, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, Seidman CE, Seidman JG, Robbins J.

CardiacmyosinbindingproteinCphosphorylationiscardioprotective. ProcNatlAcadSciUSA. 2006 Nov7;103(45):16918-23 PMC1636554

Wang H, Grant JE, Doede CM, Sadayappan S, Robbins J, Walker JW.

PKC-betaIIsensitizescardiacmyofilamentstoCa2+ byphosphorylatingtroponinIonthreonine-144. JMolCellCardiol. 2006 Nov;41(5):823-33 PMID: 17010989

Sadayappan S, Gulick J, Osinska H, Martin LA, Hahn HS, Dorn GW 2nd, Klevitsky R, Seidman CE, Seidman JG, Robbins J.

Cardiacmyosin-bindingprotein-Cphosphorylationandcardiacfunction. CircRes. 2005 Nov 25;97(11):1156-63 PMC1343494

Annapoorani P, Dhandapany PS, Sadayappan S, Ramasamy S, Rathinavel A, Selvam GS.

Cardiacisoformofalpha-2 macroglobulin-anewbiomarkerformyocardialinfarcteddiabeticpatients. Atherosclerosis. 2006 May;186(1):173-6 PMID:16102773

Sanbe A, James J, Tuzcu V, Nas S, Martin L, Gulick J, Osinska H, Sakthivel S, Klevitsky R, Ginsburg KS, Bers DM, Zinman B, Lakatta EG, Robbins J.

TransgenicrabbitmodelforhumantroponinI-basedhypertrophiccardiomyopathy. Circulation.2005 May 10;111(18):2330-8 PMC1314982

Sakthivel S, Finley NL, Rosevear PR, Lorenz JN, Gulick J, Kim S, VanBuren P, Martin LA, Robbins J.

InvivoandinvitroanalysisofcardiactroponinIphosphorylation. JBiolChem. 2005 Jan 7;280(1):703-14 PMID: 15507454

From Dr. Sadayappan’s PhD projects :

Waldmüller S, Sakthivel S, Saadi AV, Selignow C, Rakesh PG, Golubenko M, Joseph PK, Padmakumar R, Richard P, Schwartz K, Tharakan JM, Rajamanickam C, Vosberg HP.

NoveldeletionsinMYH7 andMYBPC3 identifiedinIndianfamilieswithfamilialhypertrophiccardiomyopathy. JMolCellCardiol. 2003 Jun;35(6):623-36 PMID: 12788380

Sakthivel S,Vosberg HP, Rajamanickam C.

Oligonucleotide ligation assay for rapid and sensitive identification of carriers of a missense mutation in the cardiac -myosin heavy chain gene causing hypertrophic cardiomyopathy in an Indian family. Current Science. 2001; 80 (12):1588-1592.

Rajamanickam C, Sakthivel S, Babu GJ, Lottspeich F, Kadenbach B.

Cardiac isoform of alpha-2 macroglobulin, a novel serum protein, may induce cardiac hypertrophy in rats. Basic Res Cardiol. 2001; 96: 23-33 PMID: 11215529

Chakarova C, Wehnert MS, Uhl K, Sakthivel S,Vosberg HP, Ven PFM and Fürst DO.

Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family. Hum Genet. 2000; 107:597-611 PMID: 11153914

Sakthivel S, Joseph PK, Tharakan JM, Vosberg HP, Rajamanickam C.

A novel missense mutation (R712L) adjacent to the "active thiol" region of the cardiac -myosin heavy chain gene causing hypertrophic cardiomyopathy in an Indian family. Hum Mutat. 1999; 15(3): 298-299 PMID: 10679957

Rajamanickam C, Sakthivel S, Joseph PK, Janarthanan RA.

A novel serum protein of molecular weight 182 kDa: A molecular marker for an early detection of increased LVM mass in patients with cardiac hypertrophy. J Cardiovasc Risk. 1998; 5(6): 335-338 PMID: 9920006

Sakthivel S, Renuga G, Ravindranath M, Shanmugam J, Rajamanickam C.

Impact of cardiac hypertrophy specific serum protein of molecular weight 182 kDa protein in viral induced myocarditis. Indian J. Virology. 1997; 13(2): 85-90.

Sakthivel S. and Rajamanickam C.

Molecular aspects of cardiac hypertrophy. BioBytes. 1993; 1:11-12.

For queries and opportunities, Please Contact :

Sakthivel Sadayappan, PhD, MBA
Professor, Department of Internal Medicine
Director of Heart Branch of the Heart, Lung and Vascular Institute
Division of Cardiovascular Health and Disease, College of Medicine
University of Cincinnati
Cardiovascular Center, Rm 4935
231 Albert Sabin Way
Cincinnati, OH 45267-0542, USA
Phone : +1 513-558-7498
Email : sadayasl@ucmail.uc.edu

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