Dr. Sadayappan completed his Bachelor’s degree in Botany at the American College in Madurai, India, and his Master’s degree in Botany at VHNSN College in Virudhunagar, India. He pursued his doctoral studies on the molecular aspects of cardiac hypertrophy, earning a PhD in Biochemistry from Madurai Kamaraj University, India. For his postdoctoral training, he worked at the Max-Planck Institute in Bad Nauheim, Germany, and Cincinnati Children’s Hospital in Cincinnati, Ohio.
Dr. Sadayappan began his career as an independent investigator as a tenure-track Assistant Professor at Loyola University Chicago, Maywood, Illinois, in September 2009. He was promoted to Associate Professor of Cell and Molecular Physiology in July 2014. In August 2016, he joined the University of Cincinnati's Department of Internal Medicine, Division of Cardiovascular Health and Disease, as a Professor. During his tenure at Cincinnati, he held several key positions, including Associate Chair and Vice Chair for Basic Research in Internal Medicine, Director of the Heart Branch of the Heart, Lung, and Vascular Institute, Associate Director of Basic and Translational Research in the Division of Cardiovascular Health and Diseases, Associate Director of the NORD Rare Disease Center of Excellence, and Executive Director of the Center for Cardiovascular Research. Notably, he also held two endowed chairs: the Dr. James F. Heady Endowed Chair in Medicine and the Hanna Endowed Chair of Cardiology.
Since August 2024, Dr. Sadayappan has been the Professor and Head of the Department of Cellular and Molecular Medicine at the University of Arizona, Tucson, AZ. He also serves as one of the Associate Directors of the Sarver Heart Center and holds the Czarina M. & Humberto S. Lopez Endowed Chair.
Dr. Sadayappan's research is driven by a commitment to improving cardiac health, with a long-term goal of preventing heart failure resulting from hypertrophic cardiomyopathy and coronary heart disease. His team focuses on studying the regulation of cardiac and skeletal muscles under both healthy and pathological conditions. Their research specifically aims to: (i) identify secondary risk factors such as diabetes and hypertension in the South Asian population that may exacerbate the severity of hypertrophic cardiomyopathy; (ii) uncover molecular mechanisms involved in heart failure with reduced ejection fraction and cardiac arrhythmias; (iii) explore autoimmune responses following myocardial injury; and (iv) investigate the pathology of skeletal muscle in distal arthrogryposis.
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My Life, My Heart and My(osin) binding protein-C